We are pleased to announce that the 2nd pilot rapid assessment of JA2 WP5 Strand B on ‘Renal denervation systems for treatment-resistant hypertension’ is now available.

This pilot rapid assessment evaluates the use of renal denervation systems for treatment-resistant hypertension. The intervention involves the destruction of efferent sympathetic nerves and afferent nerves within the wall of the renal arteries to reduce sympathetic nerve traffic, thereby causing a reduction in blood pressure. It is intended for people with persistent blood pressure "≥ 140/90 mm Hg" despite using at least 3 antihypertensive drugs in adequate doses, including a diuretic.

Several renal denervation systems that are available on the European market were identified. The level of existent evidence varies between the different technologies. In most studies, safety and the effect on blood pressure have been investigated. Additional studies and results will be available in coming years.

Find the pilot rapid assessment here.

Find the project plan of the pilot here.

Find the summary document of comments and authors’ replies of the review of the 2nd draft version of the pilot assessment here